Step 1: Egg Collection from patient – 10-15 eggs per cycle
Step 2: Metabolomic Assessment – identifies mitochondrial dysfunction (mtDNA depletion)
Step 3: Granulosa/Cumulus Isolation – harvest healthy mitochondria from donor cells
Step 4: Mitochondrial Enrichment – magnetic-activated sorting & concentration
Step 5: Oocyte Rescue – intracytoplasmic injection of healthy mitochondria
Step 6: Metabolic Rejuvenation – 24h culture to restore ATP production
Step 7: In-vitro Maturation (IVM) – up to 27 % euploid blastocyst rate reported
Step 8: Magnetic-activated cell sorting (MACS) – separates high-motility sperm
Step 9: Fertilization – ICSI using rejuvenated oocytes + MACS-sorted sperm
Step 10: Blastocyst Culture – extended culture to day 5-6
Step 11: Viable Embryo Rate – 82 % vs 45 % control
Step 12: Embryo Transfer – single embryo transfer recommended
Step 13: Pregnancy – clinical pregnancy rate 64 % (age-matched controls 42 %)

Journey MORE 2025
Metabolic Oocyte Rejuvenation & Enhanced Embryo Outcomes