Biological Immortality Research Vectors - Comprehensive Overview Key Research Areas for Life Extension: ## Genome Stabilization - Radical genome stabilization using error-corrected synthetic chromosomes - Programmable MHz recombinases for precise DNA maintenance - Reversible telomerase circuits to prevent cellular aging - CRISPR-based DNA damage detection systems - Multiplex repair mechanisms for genomic integrity ## Epigenetic Reset Systems - FOXM1 + OSK + Yamanaka factors in regulated pulses - Synthetic miRNA toggle switches for cellular reprogramming - Tissue-specific ABE editors to reverse senescence markers - Epigenetic clock reversal mechanisms ## Proteostasis Maintenance - Plasma-replacement proteostasis loops - Enzyme-prodrug nanoreactors with autoregulation capabilities - Engineered para-glyoxalase systems for metabolic waste clearance - In-situ chaperone ramp-up systems for protein quality control ## Cellular Replacement Infrastructure - Whole-body cellular replacement vehicles - Orthogonal CD47 variants for immune system evasion - Extracellular-matrix cloaking technologies - Tunable macrophage decoy systems - Allogeneic universal iPSC pools for tissue regeneration ## Systemic Monitoring Networks - Virus-free tissue-homing barcode reporters - Real-time biodata collection and analysis systems - Rectifiable biomarker tracking across organ systems Note: This overview is for educational and research discussion purposes only. Actual implementation would require extensive safety testing, regulatory approval, and ethical consideration.