Best longevity evidence is observational: Singapore cohort (n=4551, 11.6yr follow-up) found curry consumption (≥occasional vs never) reduced mortality 30-46% and added 1-2 years life expectancy, with linear decreases in inflammatory markers (NLR, PLR, SII) - BUT this is curry (mixed spices with turmeric), not isolated curcumin https://pmc.ncbi.nlm.nih.gov/articles/PMC10828228/ - For pure curcumin RCTs: Santos-Parker 2017 showed 2g/day (Longvida) for 12 weeks improved endothelial function dramatically in healthy middle-aged/older adults (37% ↑resistance artery, 36% ↑FMD) via increased NO bioavailability and reduced oxidative stress https://www.aging-us.com/article/101149/text - Safety is excellent: doses up to 12g/day for 3 months are well-tolerated without toxicity https://pmc.ncbi.nlm.nih.gov/articles/PMC3535097/ - However, CIMT trial at 80mg/day for 24 weeks in diabetic hemodialysis patients showed no improvement vs placebo https://pmc.ncbi.nlm.nih.gov/articles/PMC10935569/ - Bottom line: no direct RCTs on all-cause mortality with pure curcumin, but strong mechanistic evidence for vascular aging reversal at 2g/day doses.