05:44 < fenn> superkuh: thoughts about extracting the zinc ionophore pyrithione from shampoo as a stopgap coronavirus treatment? 05:46 < fenn> should i be telling people to start shampooing with head & shoulders? 05:47 < fenn> maybe that's a waste of precious shampoo 06:20 < nsh> what does this do? 06:27 < fenn> zinc ionophores increase the intraceullular zinc levels, and zinc ions inhibit coronavirus RNA-dependent RNA polymerase. it's one possible mechanism for why chloroquine has an antiviral effect 06:46 < fenn> .title https://www.ncbi.nlm.nih.gov/pubmed/29471083 06:46 < saxo> Imaging the penetration and distribution of zinc and zinc species after topical application of zinc pyrithione to human skin. - PubMed - NCBI 06:46 < fenn> 250x increase in skin cell zinc levels after 48hr 06:51 < fenn> seems to cause oxidative damage by inducing mitochondrial malfunction 06:51 < fenn> pretreatment with antioxidants afforded protection (in vitro) 06:56 < fenn> smearing shampoo all over your skin might increase blood levels of pyrithione enough to raise zinc levels in mucous membrane and lung epithelial cells, or it may just stay in the skin and suck away all available zinc 06:57 < fenn> best to do it only if you're also taking a zinc supplement 12:54 < fenn> i'm suggesting everyone take zinc supplements, eat foods high in flavonoids (red onions, kale, capers) and/or take quercetin, EGCG, ubiqinol 12:54 < Ashstar> resveratrol 12:54 < fenn> i'm currently researching pyrithione but i'm not sure whether it will do more harm than good 13:02 < fenn> practically speaking i have no idea how effective this diet recommendation actually is 13:02 < fenn> i'd give everyone hydroxochloroquine if i could 13:03 < fenn> starting with doctors, then old people, then everyone else 13:03 < fenn> it's been done before, entire countries given chloroquine to prevent malaria http://youtu.be/U7F1cnWup9M Coronavirus Epidemic Update 34: US Cases Surge, Chloroquine & Zinc Treatment Combo, Italy Lockdown http://youtu.be/vE4_LsftNKM Coronavirus Pandemic Update 35: New Outbreaks & Travel Restrictions, Possible COVID-19 Treatments https://www.researchgate.net/profile/Milan_Nagy/publication/248391287/figure/fig1/AS:298293906165766@1448130217654/Structures-of-resveratrol-quercetin-kaempferol-and-isorhamnetin.png http://ncbi.nlm.nih.gov/pubmed/25050823 Zinc ionophore activity of quercetin and epigallocatechin-gallate: from Hepa 1-6 cells to a liposome model. http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1001176 Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture https://www.youtube.com/watch?v=VQy44hFpnM0 Evolution Head and Shoulders/Firetruck Movie Clip 10 micromolar chloroquine has the same effect as raising zinc concentration 10x comments from derek lowe's blog: "Treating a symptomatic patient, likely with advanced signs, is closing the barn doors after the horse is in another state. The patients struggling to breathe have alveolar spaces full of fluid, fibrin and inflammatory cells, not virus. Assuming you have an antiviral that can actually decrease viral entry into cells or replication, for it to have an impact you’d need to administer as a preventative, or to patients that have just turned positive but are still asymptomatic" "azithromycin, which (supposedly, according to at least one study) has some effectiveness at reducing the overproduction of mucus" foods with flavan-3-ols (like quercetin or EGCG) highest dose per serving listed first: - dock 900ppm quercetin - capers - red onions - elderberries - red wine - cocoa (dark chocolate, not treated with alkali) - cilantro 550ppm quercetin - radicchio 290ppm quercetin - watercress 280ppm quercetin - onion 200ppm quercetin - kale 210ppm quercetin (but let's be honest here, how much kale can you really eat) - okra 190ppm quercetin many foods high in flavonoids are also high in oxalates, which can cause kidney stones, so i recommend taking less than a tablespoon of magnesium citrate solution without having fat in the same meal which prevents the magnesium from being absorbed. yeah it's gross. dilute with water. you don't have to eat the quercetin-containing foods and magnesium at the same time.